Description
Product Characteristics:
Aliases: dJ324O17.1 antibody, H13 antibody, hIMP1 antibody, Histocompatibility (minor) 13 antibody, HM13 antibody, HM13_HUMAN antibody, IMP-1 antibody, IMP1 antibody, IMPAS antibody, IMPAS-1 antibody, Intramembrane protease 1 antibody, Intramembrane protease antibody, Minor histocompatibility antigen 13 antibody, Minor histocompatibility antigen H13 antibody, MSTP086 antibody, OTTHUMP00000030527 antibody, OTTHUMP00000030528 antibody, OTTHUMP00000030530 antibody, OTTHUMP00000214528 antibody, Presenilin-like protein 3 antibody, PSENL3 antibody, PSL3 antibody, Signal peptide peptidase antibody, Signal peptide peptidase beta antibody, SPP antibody
Target Information: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (By similarity). May play a role in graft rejection